Common Side Effects of Reglan. You should tell your doctor if any of the following side effects are severe or don't go away: Excessive fatigue; Drowsiness DESCRIPTION. For oral administration, reglan ® tablets (metoclopramide tablets, USP) 10 mg are white, scored, capsule-shaped tablets engraved “REGLAN” on one side and “ANI 10” on the opposite side. Reglan has often been used in the U.S. One major side-effect of Reglan is severe depression; it is contraindicated in moms with a history of depression, and all moms who take this should keep an eye out for signs of depression. Pictures of Reglan (Metoclopramide), drug imprint information, side effects for the patient. Reglan Injection (metoclopramide injection, USP) is a clear, colorless, sterile solution with a pH of 4.5-6.5 for intravenous (IV) or intramuscular (IM) administration. Common adverse drug reactions (ADRs) associated with metoclopramide therapy include restlessness , and focal dystonia. Infrequent ADRs include hypertension, hypotension, hyperprolactinaemia leading to galactorrhea, depression, headache, and extrapyramidal effects such as oculogyric crisis. What other drugs will affect Reglan? Using Reglan with other drugs that make you drowsy can worsen this effect. Ask your doctor before you take opioid pain medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Domperidone. Introduction: Domperidone (Motilium™) is a drug that has, as a side effect, the increase of milk production, probably by increasing prolactin production by the pituitary gland. 2 mg/kg/dose IV infusion, given 30 minutes prior to chemotherapy, then repeated at intervals 2 to 4 hours later (Max: 5 doses/day) have been used for highly emetogenic chemotherapy regimens. 1 mg/kg/dose IV infusion regimens have been used clinically for less emetogenic chemotherapy. We noticed that messages posted in the chat room ask about symptoms and side effects of treatment. Most want to know if a certain condition that you or your loved one is experiencing is unusual or cause for alarm.